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The United States Senate is comprised of 100 Senators, with each of the 50 states represented by two Senators. This structure is established by the U.S. Constitution, ensuring equal representation for each state in the Senate regardless of its population size. This means that even smaller states have the same number of Senators as larger states, contributing to a balance of power.

In total, with two Senators from each of the 50 states, the total number of Senators is 100. This design is a fundamental aspect of the bicameral legislature of the U.S. Congress, which is made up of the Senate and the House of Representatives. Understanding this structure is key to grasping how political representation is organized at the federal level in the United States.