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The Secretary of Defense is primarily responsible for overseeing the nation's military operations and policies. This position involves managing the Department of Defense and ensuring that the armed forces are prepared to protect the country and carry out military missions. The Secretary advises the President on defense matters and implements military policies, strategies, and defense plans.

The role focuses on national security, military readiness, and the proper functioning of the U.S. armed forces, which includes administrative and operational control over various branches of the military. Therefore, option B accurately reflects the duties and responsibilities associated with the Secretary of Defense, distinguishing it from the other choices, which pertain to different sectors of government responsibilities, such as the judiciary, health policy, and economic matters.